Serum microRNAs - potent biomarkers for radiation biodosimetry

Serum microRNAs – potent biomarkers for radiation biodosimetry

Identification of Sensitive Serum microRNA Biomarkers for Radiation Biodosimetry

Exposure to ionizing radiation through environmental, occupational or a nuclear reactor accident such as the recent Fukushima Daiichi incident often results in major consequences to human health. The injury caused by radiation can manifest as acute radiation syndromes within weeks in organs with proliferating cells such as hematopoietic and gastrointestinal systems. Cancers, fibrosis and degene...

Gene-Expression Biomarkers for Application to High-Throughput Radiation Biodosimetry

Molecular biodosimetry tools are a valuable asset for life-saving medical triage and patient management following a radiological or nuclear disaster. Even with the delayed onset of symptoms, sometimes several days after exposure, gene-expression biomarkers can identify these exposed individuals very early after exposure, allowing for prompt medical intervention. This early assessment of a radia...

-MicroRNAs: New biomarkers for diagnosing HIV-

According to the increasing number of AIDS patients and their deaths, Treatment is a very important debate to prevent this Which is dependent on early and Accurate diagnosis. Currently, there are different diagnostic methods, including virus cultures, rapid tests, western blot, and other tests for this infection. Among these, HIV RNA TESTING, especially APTIMA HIV RNA ASSAY and fourth generatio...

Serum MicroRNAs Are Promising Novel Biomarkers

BACKGROUND Circulating nucleic acids (CNAs) offer unique opportunities for early diagnosis of clinical conditions. Here we show that microRNAs, a family of small non-coding regulatory RNAs involved in human development and pathology, are present in bodily fluids and represent new effective biomarkers. METHODS AND RESULTS After developing protocols for extracting and quantifying microRNAs in s...